Mr Sharma and other ministers from his department are holding daily virtual meetings with business leaders to work out ways their staff can get back to factories, construction sites or offices without breaking social distancing rules.
A Downing Street source said: If people are within the rules and follow social distancing guidance, we are more than happy for businesses to resume on that basis.
Companies including Persimmon and Taylor Wimpey have been applauded by ministers for re-opening their construction sites, saying firms were taking an essential step in getting the economy moving.
Car firms including Nissan, Aston Martin and Jaguar Land Rover have announced plans to reopen their factories with strict safety measures in place following talks with the Government.
Business Minister Nadhim Zahawi held a conference call on Friday evening with industry leaders and asked how the Government could help revive their operations as part of early steps to restart the economy.
A source said: Governments attention has changed from the car industrys survival to restarting work.    
BMW, Bentley, Toyota, JCB and Caterpillar have also been in the talks, with Whitehall officials suggesting perspex shields could be introduced between workers on production lines to make factories safe.
Talks have also been held with the business services sector this week, including executives from the Arup Group and McKinsey & Company, as well as leading accountancy, advertising and legal firms.
Robert Jenrick, the Housing Secretary, said Persimmons decision to reopen sites was another big step forward for housing and construction. He also welcomed the decision of Britains biggest brick manufacturer, Ibstock, to reopen its 21 brickworks on Monday, saying: The reopening of the supply chain is an essential step.
McDonalds plans to re-open drive-through restaurants in mid-May, and British Steel will resume production at its Skinningrove plant in North Yorkshire on Monday. Mr Jenrick also thanked councils for answering his call to reopen hundreds of parks this weekend.
The gradual return to work will put pressure on the Government to explain how and when schools will reopen and also calls into question the decision by Transport for London to furlough workers when more public transport may soon be needed.
Prof Whitty told MPs the reproduction rate of the virus – the so-called R number – was now below the key figure of one, meaning each infected person passes the virus on to fewer than one other person on average, keeping the spread at manageable levels.